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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '19cd50b3b0b74f728192a7a7e450e1b09a7ad42506bbf715f7a763cc1fb31a09' 
  AND token = '2F4V+EDtQz6tyPy90HAf7GkpSg0EpIFBXKlYYOO3ya4=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00033

JSON explain

{
  "query_block": {
    "select_id": 1,
    "table": {
      "message": "Impossible WHERE noticed after reading const tables"
    }
  }
}