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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '65c2f41d49507a136da6083c079a07930543f36a06c84ac966023698b07374f9' 
  AND token = '8VrMr6adqoKoBqTOlBhaO6OsQCJBRHWJlV5+rMn2OP4=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00027

JSON explain

{
  "query_block": {
    "select_id": 1,
    "table": {
      "message": "Impossible WHERE noticed after reading const tables"
    }
  }
}