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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '177c9d37f1027a66b81523ecc5406da1b75cf7a14aecdee7940a7622845ab9f9' 
  AND token = 'sI2EkIZBYY2lqMzxHefp7yrMsItSQfR9pzY9xDwhbFg=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00024

JSON explain

{
  "query_block": {
    "select_id": 1,
    "table": {
      "message": "Impossible WHERE noticed after reading const tables"
    }
  }
}