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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'ee3438c1c5e42964096a568b9ea1d785253d54f9d7b844a671df701da3285111' 
  AND token = '5IiavHFqexLPTBEndmoNgJIQ0v+zb3FqBsTzfBuxdn4=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "table": {
      "message": "Impossible WHERE noticed after reading const tables"
    }
  }
}