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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '21db157a8bd2ba44568e3c8f69ac05a50b70b430b1377df0332279fc4fbb4728' 
  AND token = 'VO8uORFmL1mu2zTq21pb+K1XkCe6skp16Fg7CyM5OA4=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00024

JSON explain

{
  "query_block": {
    "select_id": 1,
    "table": {
      "message": "Impossible WHERE noticed after reading const tables"
    }
  }
}