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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '543cf3e7c70e693156e473ddfb434fa2b8066e80cdaa94695ebf6c7c10d69456' 
  AND token = 'c4GJx/zr5+eY6WlT4WnQHXFrX9QdUC6ZniexR2Vi5ZE=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00021

JSON explain

{
  "query_block": {
    "select_id": 1,
    "table": {
      "message": "Impossible WHERE noticed after reading const tables"
    }
  }
}