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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '8e5281509b47d7bd78239cf6e59e81794073386538f9a3f0e00178bc5f2982f8' 
  AND token = 't/M3DpdJ96Q3ywKDXr/r0D6/mZ+SR9SxWoJ7/km/4rY=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "table": {
      "message": "Impossible WHERE noticed after reading const tables"
    }
  }
}