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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '6e0ccb2e89782f5d9c669f34aa9e88759259826c91fa21a18e1aece19fcad88a' 
  AND token = 'czXtGb/+QagDtqjUtx1isPQteL0LmlJDBc8FLW07fp4=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00030

JSON explain

{
  "query_block": {
    "select_id": 1,
    "table": {
      "message": "Impossible WHERE noticed after reading const tables"
    }
  }
}