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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '165f9dc56629ab5ae25d206f357f8f857a263811cbbd824f63ef6166955a904d' 
  AND token = 'eJAaaXnTlx2bQCbS2uGSY/zDYuvqkTEq+F8v9hSbp08=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00027

JSON explain

{
  "query_block": {
    "select_id": 1,
    "table": {
      "message": "Impossible WHERE noticed after reading const tables"
    }
  }
}